Upon submission, in your cover letter, please include the names of at least eight potential reviewers, in the relevant field of research, to review your manuscript. In light of this, please ensure that there are no conflicts of interest.
Call for Papers: Stem cell therapy for pediatric diseases: innovations, challenges, and future directions
Edited by: Mahmood Choudhery, PhD, University of Health Sciences, Pakistan
Submission Status: Open until 3 November 2025
Call for Papers: Fibrotic diseases: from models to therapies
Edited by: Professor Nai-Chen Cheng, MD, PhD, National Taiwan University Hospital, Taiwan
Submission Status: Open until 3 November 2025
Call for Papers: Clinical and Preclinical Evidence in Regenerative Cardiology
Edited by: Armin Attar, MD, PhD, Shiraz University of Medical Sciences, Iran
Submission Status: Open until 15 July 2025
Call for Papers: Mesenchymal Stem Cell (MSCs) and MSC-Derived Extracellular Vesicles: Roles in Regenerative Medicine and Beyond
Edited by: Hongcui Cao, PhD, Zhejiang University, China
Submission Status: Open until 15 August 2025
Call for Papers: Clinical Trials in Regenerative Medicine and Their Challenges
Edited by: Akihiro Umezawa, PhD, National Research Institute for Child Health and Development, Japan
Submission Status: Open until 30 June 2025
Featured articles
Featured Review: Cell-based regenerative and rejuvenation strategies for treating neurodegenerative diseases
Neurodegenerative diseases including Alzheimer’s and Parkinson’s disease are age-related disorders which severely impact quality of life and impose significant societal burdens. Cellular senescence is a critical factor in these disorders, contributing to their onset and progression by promoting permanent cell cycle arrest and reducing cellular function, affecting various types of cells in brain. Recent advancements in regenerative medicine have highlighted “R3” strategies—rejuvenation, regeneration, and replacement—as promising therapeutic approaches for neurodegeneration. This review aims to critically analyze the role of cellular senescence in neurodegenerative diseases and organizes therapeutic approaches within the R3 regenerative medicine paradigm. Specifically, we examine stem cell therapy, direct lineage reprogramming, and partial reprogramming in the context of R3, emphasizing how these interventions mitigate cellular senescence and counteracting aging-related neurodegeneration. Ultimately, this review seeks to provide insights into the complex interplay between cellular senescence and neurodegeneration while highlighting the promise of cell-based regenerative strategies to address these debilitating conditions.
Authors: Sixiu Deng, Huangfan Xie & Bingqing Xie
Published: 06 April 2025
Featured Article: Extracellular vesicles from hiPSC-derived NSCs protect human neurons against Aβ-42 oligomers induced neurodegeneration, mitochondrial dysfunction and tau phosphorylation
Alzheimer’s disease (AD) is characterized by the accumulation of amyloid beta-42 (Aβ-42) in the brain, causing various adverse effects. Thus, therapies that reduce Aβ-42 toxicity in AD are of great interest. One promising approach is to use extracellular vesicles from human induced pluripotent stem cell-derived neural stem cells (hiPSC-NSC-EVs) because they carry multiple therapeutic miRNAs and proteins capable of protecting neurons against Aβ-42-induced toxicity. Therefore, this in vitro study investigated the proficiency of hiPSC-NSC-EVs to protect human neurons from Aβ-42 oligomers (Aβ-42o) induced neurodegeneration.
Authors: Shama Rao, Leelavathi N. Madhu, Roshni Sara Babu, Goutham Shankar, Sanya Kotian, Advaidhaa Nagarajan, Raghavendra Upadhya, Esha Narvekar, James J. Cai & Ashok K. Shetty
Published: 18 April 2025
Additional Cover Letter Guidelines
Articles
-
-
Mesenchymal stem/stromal cells as a therapeutic for sepsis: a review on where do we stand?
-
Lyophilized MSC-EVs attenuates COVID-19 pathogenesis by regulating the JAK/STAT pathway
-
Human umbilical cord mesenchymal stem cell therapy for atopic dermatitis through inhibition of neutrophil chemotaxis
-
The role of adipose-derived stem cells in knee osteoarthritis treatment: insights from a triple-blind clinical study
-
Stem cells: past, present, and future
-
Ethical issues in stem cell research and therapy
-
CAR T cells in solid tumors: challenges and opportunities
-
Platelet-rich plasma preparation for regenerative medicine: optimization and quantification of cytokines and growth factors
-
Stem cells: a potential treatment option for kidney diseases
2025
Topical collection
Stem cell therapy for pediatric diseases: innovations, challenges, and future directions
Edited by Mahmood Choudhery
Topical collection
Fibrotic diseases: from models to therapies
Edited by Nai-Chen Cheng
2024
Topical collection
Clinical and Preclinical Evidence in Regenerative Cardiology
Edited by Armin Attar
Topical collection
Mesenchymal Stem Cell (MSCs) and MSC-Derived Extracellular Vesicles: Roles in Regenerative Medicine and Beyond
Edited by Hongcui Cao
Topical collection
Clinical Trials in Regenerative Medicine and Their Challenges
Edited by Akihiro Umezawa
2023
Topical collection
Stromal cells and progenitor cells for osteoarticular regeneration
Edited by Christian Jorgensen
Topical collection
Organoids and Tissue/Organ Chips
Edited by Albert J Banes and Rajashekhar Gangaraju
2021
Thematic series
Adult stem cells in retinal diseases: where do we go from here?
Edited by Rajashekhar Gangaraju
Thematic series
Stem cell therapy of COVID-19 and other respiratory diseases
Edited by Hong-Long James Ji, Michael A. Matthay and Yuanlin Song
Thematic series
NK cells as the next option for cancer treatment
Edited by Michael O'Dwyer
2020
Cross-journal collection
Coronavirus research highlights
Thematic series
Stem cells and gene editing
Edited by Stephen H. Tsang
2018
Cross-journal collection
Pluripotent Stem Cells
2017
Thematic series
Regenerative neurology
Edited by Simon Koblar and Anne Hamilton-Bruce
2015
Thematic series
Extracellular vesicles and regenerative medicine
Edited by Jeffrey Karp, Kelvin Ng and Armand Keating
Cross-journal collection
Mesenchymal stem/stromal cells – an update
Edited by Richard Schäfer and Selim Kuci
Cross-journal collection
Biology and clinical applications of stem cells for autoimmune and musculoskeletal disorders
Edited by Christian Jorgensen and Anthony Hollander
2014
Thematic series
Functional imaging in regenerative medicine
Edited by Timothy O'Brien and Rocky Tuan
Thematic series
Emerging investigators
Edited by Timothy O'Brien and Rocky Tuan
Thematic series
Stem cells and genitourinary regeneration
Edited by John D Jackson
2013
Thematic series
Cardiovascular regeneration
Edited by Ronald Li
2012
Thematic series
Physical influences on stem cells
Edited by Gordana Vunjak-Novakovic
Thematic series
Stem cell research in the Asia-Pacific
Edited by Oscar Lee, Songtao Shi, Yufang Shi and Ying Jin
Thematic series
Clinical applications of stem cells
Edited by Mahendra Rao
2011
Review series
Immunology and stem cells
Edited by Christian Jorgensen
Review series
Epigenetics and regulation
Review series
Stem cell niche
2010
Review series
Induced pluripotent stem cells
Trending articles in Stem Cell Research & Therapy
Click here to view which Articles have been shared the most in the last quarter!
Stem Cell Research & Therapy: 10th Anniversary
To mark the 10th year anniversary, we have reviewed the milestone achievements and highlighted some of the best content selected by our Editors-in-Chief and Associate Editors. Read more here.
Editors-in-Chief
Rocky S Tuan, The Chinese University of Hong Kong, Hong Kong SAR, China
Timothy O'Brien, University of Galway, Ireland: Prof Timothy O’Brien is the Established Professor of Medicine in the College of Medicine, Nursing and Health Sciences at University of Galway and Consultant Endocrinologist in University Hospital Galway. He established the Regenerative Medicine Institute (REMEDI) with Prof Frank Barry in 2004 and is currently co-PI of the SFI-funded Centre for Research and Medical Devices (CÚRAM). Prof O’Brien’s research explores the synergies between gene therapy, stem/stromal cell therapy and biomaterials science with a key interest in the development of therapies for diabetic complications. The objective of his research is to translate research findings in the laboratory to clinical trials.
Journal submission information
Before you submit your manuscript to Stem Cell Research & Therapy, please ensure you have read and noted the below:
- Authors are requested to provide institutional email addresses. At the minimum, at least the corresponding author and submitting author should provide an institutional email address.
- Image integrity and standards: Cropped gels and blots can be included in the main text if it improves the clarity and conciseness of the presentation. In such cases, the cropping of the blot must be clearly evident and must be mentioned in the figure legend. Corresponding uncropped full-length gels and blot must be included in the supplementary files. These uncropped images should indicate where they were cropped, be labelled as in the main text and placed in a single supplementary figure. The manuscript's figure legends should state that 'Full-length blots/gels are presented in Supplementary Figure X'. Further information can be found under 'Digital image integrity' which are detailed on our Standards of Reporting page.
- Authors should clearly declare in the Acknowledgement Section if there is any work that was outsourced or data not collected by authors.
- Authors might be asked to provide original source data (raw data / original data / individual data points) if the reviewers or editors have any question.
- Authors should provide these information in the ethics declaration if the study involve human participants, human material, human data, or animals: (1) Title of the approved project; (2) Name of the institutional approval committee or unit; (3) Approval number; (4) Date of approval. Authors might be asked to provide ethics approval documents if the reviewers or editors have any question.
Aims and scope
Stem Cell Research & Therapy is the major forum for translational research into stem cell therapies. An international peer-reviewed journal, it publishes high-quality open access research articles with a special emphasis on basic, translational and clinical research into stem cell therapeutics and regenerative therapies, including animal models and clinical trials. The journal also provides reviews, commentaries, reports and methods.
Please note that we do not accept pre-clinical systematic reviews, case reports, or meta-analyses.
Topics covered include, but are not limited to:
- Adult stem cells
- Animal models
- Biophysics and mechanobiology
- Cancer stem cells
- Cell culture and manufacture
- Clinical studies
- Disease modeling and drug screening
- Embryonic stem cells
- Ethical, legal and social aspects
- Genetics and epigenetics
- Genomics/proteomics/metabolomics
- Germ cells
- Immunology
- Induced pluripotent stem cells
- Regenerative medicine
- Stem cell differentiation, proliferation and migration
- Stem cell therapy/transplantation
- Technologies
- Tissue engineering and biomaterials
Announcing the launch of In Review
Stem Cell Research & Therapy, in partnership with Research Square, is now offering In Review. Authors choosing this free optional service will be able to:
- Share their work with fellow researchers to read, comment on, and cite even before publication
- Showcase their work to funders and others with a citable DOI while it is still under review
- Track their manuscript - including seeing when reviewers are invited, and when reports are received
Editors' quotes
"Stem cells have enormous potential for alleviating suffering for many diseases which currently have no effective therapy. The field has progressed to the clinic and it is important that this pathway is underpinned by excellent science and rigorous standards of clinical research. The journal provides an important avenue of publication in translational aspects of stem cell therapy spanning preclinical studies, clinical research and commercialization."
Timothy O'Brien, Editor-in-Chief, Stem Cell Research & Therapy
"The study of stem cells is one of the most exciting areas of contemporary biomedical research. We believe that Stem Cell Research & Therapy will act as a highly active forum for both basic and translational research into stem cell biology and therapies. Specifically, by developing this forum for cutting edge research, we hope that Stem Cell Research & Therapy will play a significant role in bringing together the critical information to synergize stem cell science with stem cell therapies."
Rocky S Tuan, Editor-in-Chief, Stem Cell Research & Therapy
Follow
Annual Journal Metrics
-
Citation Impact 2023
Journal Impact Factor: 7.1
5-year Journal Impact Factor: 7.9
Source Normalized Impact per Paper (SNIP): 1.277
SCImago Journal Rank (SJR): 1.798Speed 2024
Submission to first editorial decision (median days): 16
Submission to acceptance (median days): 126Usage 2024
Downloads: 4,339,054
Altmetric mentions: 1,003