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  1. Alveolar‒capillary barrier disruption is a hallmark of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). The contribution of necroptosis to the compromised alveolar-barrier in ALI remains...

    Authors: Tao Ruan, Jiaming Han, Chengxu Xue, Fengyuan Wang and Juntang Lin
    Citation: Stem Cell Research & Therapy 2025 16:250
  2. Diabetes mellitus (DM) is a grave autoimmune disorder because of no insulin self-generation. Currently, mainly clinical methods exist, serious adverse effects leading to stem cell therapy are considered. The m...

    Authors: Hanluo Li, Cheng Chen, Yuansheng Wang, Wei Yi, Peipei Guo, Chenguang Yao, Jinbiao Liu, Yanhong Wei, Kanghong Hu, Xiaoke Shang and Sini Kang
    Citation: Stem Cell Research & Therapy 2025 16:249
  3. Glucagon-like peptide-1 is an enteric proinsulin hormone secreted by intestinal L-cells that orchestrates insulin secretion in a glucose-dependent manner. Renowned for preserving pancreatic β-cell mass, glucag...

    Authors: Zi’an Shao, Xiaoguang Zhang, Junrong Cai and Feng Lu
    Citation: Stem Cell Research & Therapy 2025 16:248
  4. Cardiovascular diseases are the main cause of death and disability in the clinical setting. Among several pathological conditions, myocardial infarction (MI) is a common clinical finding and happens due to the...

    Authors: Narges Mardi, Parisa Khanicheragh, Zahra Abbasi-Malati, Solmaz Saghebasl, Nafiseh Didar Khosrowshahi, Sara Aghakhani Chegeni, Farzin Javid, Mahdiyeh Azari, Leila Salimi, Aysa Rezabakhsh, Soheil Zamen Milani and Reza Rahbarghazi
    Citation: Stem Cell Research & Therapy 2025 16:247
  5. Mesenchymal stem cells have shown promise in many areas of regenerative medicine due to the anti-inflammatory and pro-regenerative effects of the secreted factors. However, successful delivery remains problema...

    Authors: Ami Nash, I-Ning Lee, Graeme Fox, James Phillips, Lisa J White and Maria Marlow
    Citation: Stem Cell Research & Therapy 2025 16:246
  6. Sepsis is one of the leading causes of morbidity and mortality in the United States and Worldwide despite advances in quick recognition and early antibiotics, fluids, and vasopressors. Mesenchymal stem/stromal...

    Authors: Courtney Premer, Joshua M. Hare, Sarah Y. Yuan and Jason W. Wilson
    Citation: Stem Cell Research & Therapy 2025 16:245
  7. The JAK/STAT signaling pathway plays a crucial role in the release of interferons (IFNs) and the proinflammatory response during SARS-CoV-2 infection, contributing to the cytokine storm characteristic of sever...

    Authors: Nesrine Ebrahim, Hajir A. Al Saihati, Zahraa Alali, Sabry Younis Mohamed Mahmoud, Ali A. Rabaan, Arigue A. Dessouky, Rabab F. Salim, Ashraf A. Shamaa, Ahmed N. Abdallah, Nehal M. Elsherbiny, Gamal Othman, Abdelnaser A. Badawy, Gianpiero Di Leva and Omnia A. Badr
    Citation: Stem Cell Research & Therapy 2025 16:244
  8. Atopic dermatitis (AD) management is significantly challenging due to the high prevalence, chronicity, and recurrent nature of the disease, and limited options for its treatment. Human umbilical cord mesenchym...

    Authors: Jinjin Shao, Zhiqi Xie, Zhichao Ye, Guoyu Chen, Yiru Wang, Lili Zhang, Fang Liu, Siming Zhang, Xiaobo Lin, Jiahong Wang, Ying Chen, Yunxiang Chen, Xin Pan, Feifei Wu, Ruolang Pan, Jinfeng Liang…
    Citation: Stem Cell Research & Therapy 2025 16:243
  9. Osteoarthritis (OA) is a degenerative joint disease that primarily affects older adults, characterized by cartilage degradation, synovitis, and osteophyte formation. Despite its prevalence, no medical treatmen...

    Authors: Simin Sajadi, Mohammad Amin Khadembashiri, Gholamreza Raissi, Mohamad Mehdi Khadembashiri, Korosh Mansouri, Homayoun Hadizadeh-Kharazi, Mohammad Taghi Joghataei, Seyed Pezhman Madani, Bijan Forogh and Sina Parsipour
    Citation: Stem Cell Research & Therapy 2025 16:242
  10. Psoriasis is defined as a persistent autoimmune disease characterized by the appearance of psoriatic lesions on the surface of the skin. Currently, various approaches including chemicals, corticosteroids, phot...

    Authors: Mohammadreza Dashti, Mojgan Mohammadi, Sajad Dehnavi and Mahvash Sadeghi
    Citation: Stem Cell Research & Therapy 2025 16:241
  11. Fine particulate matter (PM2.5) exposure significantly exacerbates respiratory morbidity, particularly in asthmatic individuals, highlighting an urgent need for effective therapeutic interventions. In this study,...

    Authors: Jianling Liu, Yuehua Chen, Zhongpeng Li, Zhangwen Li, Fengjuan Lyu, Fang Wang, Aili Wang, Zhangquan Liu, Xiaoyang Liao and Jian Wu
    Citation: Stem Cell Research & Therapy 2025 16:240
  12. Premature ovarian insufficiency (POI) poses a significant threat to female reproductive health and currently lacks effective interventions. Recent studies highlight the promising potential of human pluripotent...

    Authors: Xinran Li, Jinrong Liao, Youhong Zheng, Wei Cai, Jie Chen, Yu Liang, Yuanmei Chen, Xiaoxuan Li, Jiamao Luo, Jiaxin Xie, Manping Zhou, Lilin Hang, Xiujuan Sun, Xin Yue, Xuefeng Wang, Yifeng Wang…
    Citation: Stem Cell Research & Therapy 2025 16:239
  13. In recent years, therapeutic preparations using patient-derived tissues have emerged as commercially approved regenerative medicine products for expanding treatment possibilities for patients with no other tre...

    Authors: Masao Sasai, Yayoi Kitawaki, Akihiro Umezawa, Yoshinori Oie, Takahiro Kamiya, Takuji Kawamura, Yoji Sato, Satoshi Hosoya, Hiroyuki Sugawara, Kazuto Yamada, Hiroshi Izumoto, Yoshiyuki Mae, Tohru Kuroda and Kiyoshi Okada
    Citation: Stem Cell Research & Therapy 2025 16:238
  14. Avulsion injury results in motoneuron death due to the increased cytotoxicity developing after the injury. We have earlier shown that intraspinally grafted immortalized NE-4C neuroectodermal stem cells derived...

    Authors: Tamás Bellák, Zoltán Fekécs, Dénes Török, Rebeka Kristóf, Omoikhoje Esezoobo, Annamária Marton, Csaba Vizler, Antal Nógrádi and Krisztián Pajer
    Citation: Stem Cell Research & Therapy 2025 16:237
  15. Myocardial infarction (MI) is a severe disease that often associated with impaired angiogenesis and increased myocardial apoptosis. Mesenchymal stromal cells (MSCs) have been a promising candidate for treating...

    Authors: Mingjie Pan, Yueyue Xu, Yaping Wang, Yue Jiang, Yuanyuan Xie, Chenxu Tai, Wenqing Wang and Bin Wang
    Citation: Stem Cell Research & Therapy 2025 16:236
  16. Osteoarthritis (OA) is a common degenerative disease caused by multiple pathological mechanisms wherein subchondral bone malfunction plays a substantial role. Recently, subchondral (SC) injection of orthobiolo...

    Authors: Congzi Wu, HuiHui Xu, Zhen Wu, Haipeng Huang, Qinwen Ge, Jianbo Xu, Jiali Chen, Pinger Wang, Wenhua Yuan, Hongting Jin and Peijian Tong
    Citation: Stem Cell Research & Therapy 2025 16:235
  17. Junctophilin-2 (JPH2) is a vital protein in cardiomyocytes, anchoring T-tubule and sarcoplasmic reticulum membranes to facilitate excitation-contraction coupling, a process essential for cardiac contractile fu...

    Authors: Tianwei Guo, Hongyue Wang, Fujian Wu, Wenjing Lu, Min Zhu, Shuhong Ma, Yongshuai Zhang, Yuting Yan, Meng Zhou, Didaer Talanaite, Siyu Liu, Man Qi, Feng Lan and Xujie Liu
    Citation: Stem Cell Research & Therapy 2025 16:234
  18. Inflammatory bowel disease (IBD), a chronic immune disorder, has increasing global incidence and poor treatment outcome. Abnormal macrophage function is implicated in the pathophysiology of IBD. In this study,...

    Authors: Mengjiao Zhou, Bing Pei, Peipei Cai, Chengxue Yi, Francis Atim Akanyibah, Changkun Lyu and Fei Mao
    Citation: Stem Cell Research & Therapy 2025 16:233
  19. Parkinson’s disease (PD) is a complex neurological disorder characterized by the progressive degeneration of midbrain dopaminergic (mDA) neurons in the substantia nigra (SN). This degeneration disrupts the basal ...

    Authors: Bérengère Ballion, Marie-Laure Bonnet, Sébastien Brot and Afsaneh Gaillard
    Citation: Stem Cell Research & Therapy 2025 16:232
  20. Senescence in stem cells and progenitor cells can be particularly detrimental because these cells are essential for tissue renewal and overall organismal homeostasis. In mesenchymal stromal cells (MSCs), which...

    Authors: Valeria Mazzone, Nicola Alessio, Domenico Aprile, Giovanni Galano, Roberto De Rosa, Chiara Schiraldi, Giovanni Di Bernardo and Umberto Galderisi
    Citation: Stem Cell Research & Therapy 2025 16:231
  21. Human menstrual blood-derived stem cells (MenSCs), a major class of mesenchymal stem cells (MSCs), modulate intercellular signals via paracrine factors. Previous studies found that MenSC-derived secretomes exe...

    Authors: Yangxin Fang, Lin Chen, Yin Yuan, Sining Zhou, Jiamin Fu, Qi Zhang, Ning Zhang, Yuqi Huang, Yifei Li, Li Yuan, Lijun Chen and Charlie Xiang
    Citation: Stem Cell Research & Therapy 2025 16:230
  22. Paracrine signaling plays an important role in stem cell therapy. However, it alone cannot fully explain the therapeutic mechanisms of stem cell therapy in treating heart diseases. Recently, tunneling nanotube...

    Authors: Jianghui Zhang, Hongfeng Jiang, Sa Liu, Zhong Xian, Limin Zhao, Yue Li, Wenxiu Lu, Changrong Shao and Sanbao Chai
    Citation: Stem Cell Research & Therapy 2025 16:229
  23. Elucidating the molecular mechanisms underlying orthopedic diseases is crucial for guiding therapeutic strategies and developing innovative interventions. N6-methyladenosine (m6A)—an epitranscriptomic modificatio...

    Authors: Peng Li, Chu Zhang, Wen Yin, Mijia Tao, Zhipeng Niu, Yutao Cui, Dankai Wu and Feng Gao
    Citation: Stem Cell Research & Therapy 2025 16:228
  24. Recent studies have suggested that targeting senescent cells in joint tissues may alleviate osteoarthritis (OA) progression. However, this strategy encounters significant challenges, partially due to the high ...

    Authors: Fu-Hao Yu, Bo-Feng Yin, Ming-Yu Liu, Wen-Jing Zhang, Zhi-Dong Zhao, Lei Wang, Xiao-Tong Li, Pei-Lin Li, Zhi-Ling Li, Run-Xiang Xu, Li Ding and Heng Zhu
    Citation: Stem Cell Research & Therapy 2025 16:227
  25. Spinal cord injury (SCI) often results in severe disabilities and significant socioeconomic burdens.

    Authors: Mohammadhosein Akhlaghpasand, Roozbeh Tavanaei, Maede Hosseinpoor, Maryam Golmohammadi, Ida Mohammadi, Amir Ghaffari Jolfayi, Melika Hosseinpour, Bardia Hajikarimloo, Kaveh Oraii Yazdani, Alireza Zali and Saeed Oraee-Yazdani
    Citation: Stem Cell Research & Therapy 2025 16:226
  26. Thioredoxin-interacting protein (TXNIP) plays a role in regulating endoplasmic reticulum (ER) and oxidative stress, which disrupt glucose homeostasis in diabetes. However, the impact of TXNIP deficiency on the...

    Authors: Leonardo Traini, Javier Negueruela, Bernat Elvira, Wadsen St-Pierre-Wijckmans, Valerie Vandenbempt, Carlos E. Buss, Ao Li, Israel Pérez-Chávez, Francisco Ribeiro-Costa, Mariana Nunes, Joris Messens, Daria Ezeriņa, David C. Hay, Mayank Bansal and Esteban N. Gurzov
    Citation: Stem Cell Research & Therapy 2025 16:225
  27. Extracellular vesicles (EVs) contain a variety of proteins with anti-inflammatory and immunomodulatory properties that offer promising benefits in skin therapy applications. An influx of EV proteomic studies i...

    Authors: Michelle Combe, Kathy Sharon Isaac, Jordan R. Plews and Stanislav Sokolenko
    Citation: Stem Cell Research & Therapy 2025 16:224
  28. Periodontitis is a chronic inflammatory disease and macrophages play a pivotal role in the progression of periodontitis. Mesenchymal stem cells (MSCs) have emerged as potential therapeutic agents for the treat...

    Authors: Liang Chen, Yuanqing Liu, Chenhao Yu, Pei Cao, Yiming Ma, Yiran Geng, Yu Cai, Yong Zhang, Jia Liu, Yang Li and Qingxian Luan
    Citation: Stem Cell Research & Therapy 2025 16:223
  29. Acute graft-versus-host disease (aGVHD) remains a major life-threatening complication of allogeneic haematopoietic cell transplantation (allo-HSCT), often limiting the therapeutic efficacy of allo-HSCT. Recent...

    Authors: Qing Xu, Rui Wang, Ke Sui, Yuxi Xu, Ya Zhou, Yuxuan He, Ziyi Hu, Qi Wang, Xiaodong Xie, Xiaoqi Wang, Shijie Yang, Lingyu Zeng, Jiang F. Zhong, Zheng Wang, Qingxiao Song and Xi Zhang
    Citation: Stem Cell Research & Therapy 2025 16:222
  30. Intervertebral disc degeneration is a multifactorial degenerative disease that poses a significant threat to the health of the elderly population. Current treatments primarily focus on physical therapy, medica...

    Authors: Yuxin Jin, Ouqiang Wu, Zhihua Chen, Linjie Chen, Kai Zhang, Qizhu Chen, Haijun Tian, Xinzhou Wang, Morgan Jones, Kenny Yat Hong Kwan, Yan Michael Li, Pooyan Makvandi, Xiangyang Wang, Xiang Hai, Jun Zhang and Aimin Wu
    Citation: Stem Cell Research & Therapy 2025 16:221
  31. The rapid formation and long-term maintenance of functional vascular networks are crucial for the success of regenerative therapies. The stromal vascular fraction (SVF) from human adipose tissue is a readily a...

    Authors: Gregory Reid, Giulia Cerino, Ludovic Melly, Deborah Fusco, Chunyan Zhang, Oliver Reuthebuch, Giulia Milan and Anna Marsano
    Citation: Stem Cell Research & Therapy 2025 16:220
  32. Intrauterine adhesions (IUAs) can easily cause female infertility or recurrent abortion, but there is still no effective treatment to improve the pregnancy and live birth rates in patients with IUAs. In recent...

    Authors: Enuo Peng, Yayue Zeng, Da He, Xiaojun Tan, Dabao Xu and Xingping Zhao
    Citation: Stem Cell Research & Therapy 2025 16:219
  33. Puerarin (Pue) has recently been reported to have therapeutic effects on periodontitis (PD). However, there is insufficient evidence, and the mechanism involved has not yet been revealed. This work delved to e...

    Authors: Yulan Xiang, Zelu Li, Xin He, Xiaoyang Chu, Chunyan Gao, Jiahao Guo, Yingyi Luan, Kai Yang and Dongliang Zhang
    Citation: Stem Cell Research & Therapy 2025 16:218
  34. The effectiveness of bone marrow mesenchymal stem cells (BMSCs) in post-transplantation liver fibrosis has not been studied. The aim of this study was to investigate the effect of BMSCs on liver fibrosis and t...

    Authors: Zhuyuan Si, Shengqiao Zhao, Zhixin Zhang, Tianran Chen, Ruofan Wang, Chong Dong, Kai Wang, Chao Sun, Zhuolun Song, Zhongyang Shen and Wei Gao
    Citation: Stem Cell Research & Therapy 2025 16:217
  35. Radiation induced hematopoietic failure was the primary cause of death after exposure to a moderate or high dose of whole body irradiation, causing increased challenge for nuclear or radiological treatment, so...

    Authors: Fu-Dong Chen, Biao Zhang, Li-Li Wang, Ya-Li Jia, Quan Zeng, Tao Fan, Hai-Yang Wang, Ming-Fang Xiong, Ying-Xue Lin, Jun-Nian Zhou, Wen Yue, Li Chen and Jia-Fei Xi
    Citation: Stem Cell Research & Therapy 2025 16:216
  36. Preliminary phase I clinical trial results revealed that autologous umbilical cord blood-derived mononuclear cells (UCB-MNCs) preserved right ventricular cardiac function. To establish the efficacy of intramyo...

    Authors: Carlos Gallego-Navarro, James Jaggers, Harold M. Burkhart, Waldemar F. Carlo, David L. Morales, M. Yasir Qureshi, Joseph W. Rossano, Clinton E. Hagen, Drew K. Seisler, Susana Cantero Peral and Timothy J. Nelson
    Citation: Stem Cell Research & Therapy 2025 16:215
  37. Hematopoietic stem cells (HSCs) are the primitive cells that give rise to common precursors for all blood cell lineages. Abnormalities in their number and/or function are important factors leading to the decli...

    Authors: XinYu Tang, Yan Wang and RuiRong Xu
    Citation: Stem Cell Research & Therapy 2025 16:214
  38. Suppressing bone mesenchymal stem cell (BMSC) ferroptosis is expected to optimize BMSCs-based therapy for intervertebral disc degeneration (IVDD). Our previous study revealed that Prominin-2 could protect agai...

    Authors: Yuzhu Xu, Lele Zhang, Xuanfei Xu, Yuao Tao, Pengfei Xue, Yuntao Wang, Renjie Chai and Xiaotao Wu
    Citation: Stem Cell Research & Therapy 2025 16:213
  39. Periosteum plays an important role in bone defect repair due to its rich vascular network and cells. However, natural periosteum is difficult to meet clinical requirements due to its low availability. Therefor...

    Authors: Guangzi Chen, Tao Xu, Ran Gao, Wenbin Liu, Weigang Li, Delu Zeng, Jian Li, Xuan Fang, Gaohong Sheng, Hongqi Zhao and Chaoxu Liu
    Citation: Stem Cell Research & Therapy 2025 16:212
  40. Delaying total knee arthroplasty is crucial for middle-aged patients with severe osteoarthritis. The long-term outcomes of high tibial osteotomy (HTO) remain uncertain. Recently, mesenchymal stem cells (MSCs) ...

    Authors: Bo Seung Bae, Jae Woong Jung, Gyeong Ok Jo, Seon Ae Kim, Eun Jeong Go, Mi-La Cho, Asode Ananthram Shetty and Seok Jung Kim
    Citation: Stem Cell Research & Therapy 2025 16:211
  41. Mesenchymal-stromal-cell-derived extracellular vesicles (MSC-EVs) play a key role in the paracrine effects of MSC and have demonstrated therapeutic potential in various preclinical models. However, clinical tr...

    Authors: Cristiana Ulpiano, William Salvador, Teresa Franchi-Mendes, Min-Chang Huang, Yee-Hsien Lin, Han-Tse Lin, Carlos A. V. Rodrigues, Ana Fernandes-Platzgummer, Joaquim M. S. Cabral, Gabriel A. Monteiro and Cláudia L. da Silva
    Citation: Stem Cell Research & Therapy 2025 16:210
  42. Autoimmune hepatitis (AIH) is an immune-mediated disease for which there is no effective treatment. Mesenchymal stromal cells (MSCs) have become a promising treatment, but low AIH treatment efficacy has hamper...

    Authors: Xilong Bai, Tingting Liu, Congge Li, Caie Qiu, Xiaofan Ge, Huili Gou, Hongzhi Cai, Liting Yang, Sili Wei, Wei Yang and Tianqing Li
    Citation: Stem Cell Research & Therapy 2025 16:209
  43. Extracellular vesicles (EVs) derived from human organoids are phospholipid bilayer-bound nanoparticles that carry therapeutic cargo. However, the low yield of EVs remains a critical bottleneck for clinical tra...

    Authors: Justice Ene, Chang Liu, Falak Syed, Li Sun, Danyale Berry, Pradeepraj Durairaj, Zixiang Leonardo Liu, Changchun Zeng, Sunghoon Jung and Yan Li
    Citation: Stem Cell Research & Therapy 2025 16:207
  44. Nano-zinc oxide (nZnO) has attracted significant attention in bone tissue engineering due to its antibacterial properties, anti-inflammatory effects, biocompatibility, and chemical stability. Although numerous...

    Authors: Xiu Chen, Zhenkun Weng, Hongchao Zhang, Jian Jiao, Jingjia Liang, Jin Xu, Dongmei Wang, Qian Liu, Qing Yan and Aihua Gu
    Citation: Stem Cell Research & Therapy 2025 16:206
  45. Stem cell therapy holds significant potential for promoting recovery, with numerous products currently under development. Blood-derived supplements are often essential for successful stem cell expansion, with ...

    Authors: Shinobu Wakamoto, Tomoko Furukawa, Masahito Kawabori, Mitsuaki Akino, Shiho Kato, Hisae Fuse, Sumio Ohtsuki, Yoshihiro Torimoto, Miki Fujimura and Shuichi Kino
    Citation: Stem Cell Research & Therapy 2025 16:205
  46. Intrauterine adhesion (IUA) refers to endometrial fibrosis resulting from endometrial injury and infection. In promoting the repair of the endometrium, mesenchymal stem cells therapy has shown great potential....

    Authors: Yuting Cao, Jianhong Wu, Jinyuan Huang, Xiaoyin Fan, Yi Zhang, Lin Li and Yinmei Dai
    Citation: Stem Cell Research & Therapy 2025 16:204
  47. Renal tubular injury and activation of peripheral fibroblasts are hallmarks of chronic kidney disease (CKD), suggesting a close connection between the two cell types. Exosomes transport miRNAs and other substa...

    Authors: Rong Dai, Meng Cheng, Chu-Yi Peng, Ze-Ping Cao, Hua Jin, Dong Wang, Yi-Ping Wang and Lei Zhang
    Citation: Stem Cell Research & Therapy 2025 16:203
  48. Patients with refractory dry eye disease (DED) often face the threat of diminished visual quality and have limited responses to existing treatments. Ocular injection of Mesenchymal stem cells (MSCs) has recent...

    Authors: Di Zhang, Taige Chen, Qi Liang, Xuebing Feng, Jiaxuan Jiang, Zeying Chen, Yun Tang, Yiran Chu, Bin Wang and Kai Hu
    Citation: Stem Cell Research & Therapy 2025 16:202
  49. Osteoporosis, a common bone disorder, is primarily managed pharmacologically. However, existing medications are associated with non-trivial side-effects. Sildenafil, which already finds many clinical applicati...

    Authors: Menglong Hu, Likun Wu, Erfan Wei, Xingtong Pan, Qiyue Zhu, Xv Xiuyun, Letian Lv, Xinyi Dong, Hao Liu and Yunsong Liu
    Citation: Stem Cell Research & Therapy 2025 16:201

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  • Citation Impact 2023
    Journal Impact Factor: 7.1
    5-year Journal Impact Factor: 7.9
    Source Normalized Impact per Paper (SNIP): 1.277
    SCImago Journal Rank (SJR): 1.798

    Speed 2024
    Submission to first editorial decision (median days): 16
    Submission to acceptance (median days): 126

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