Fig. 5
From: Targeting stem cell niche can protect hematopoietic stem cells from chemotherapy and G-CSF treatment
RANKL can efficiently activate the functions of osteoclasts during cytotoxic chemotherapy. a TRAP staining of mouse femoral metaphysis of PTH and P + R groups. Arrowheads: active TRAP+ osteoclasts stained in red (original magnification, ×400). b Serum TRAP-5b level also detected by ELISA (n = 5 each group). P + R mice injected with PTH and RANKL, PTH parathyroid hormone, TRAP 5b, tartrate-resistant acid phosphatase 5b