Fig. 1
From: Cytokine-induced memory-like natural killer cells for cancer immunotherapy
Schematic representation of the NK cell development, activation and cytotoxicity. a Developmental stages of NK cells, hematopoietic stem cells (HSC), common lymphoid progenitor (CLP), natural killer progenitor (NKP), immature NK (iNK) and mature NK (mNK) cells. b The NK cell function is controlled by the expression of inhibiting (left) and activating receptors (right). c Once the net balance is shifted toward the activating signals, NK cells kill their targets through the release of perforin/granzyme, FasL- and TRAIL-mediated apoptosis and antigen-dependent cellular cytotoxicity (ADCC)