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Table 2 Up-/down-regulated differentially expressed proteins (DEPs) between the responders and non-responders pre-MSC treatment

From: Plasma proteomics-based biomarkers for predicting response to mesenchymal stem cell therapy in severe COVID-19

Protein names

UniprotKB

Gene names

Mean (responders)

Mean (non-responders)

p

Up-/down-regulated

CSPG2

P13611

VCAN

15.481

14.252

0.031

Up

CTRB1

P17538

CTRB1

15.494

14.540

0.024

Up

OSCAR

Q8IYS5

OSCAR

14.718

13.254

0.025

Up

ANXA1

P04083

ANXA1

15.973

17.200

0.005

Down

AGRG6

Q86SQ4

ADGRG6

16.955

17.639

0.016

Down

CAPG

P40121

CAPG

13.617

14.336

0.040

Down

DDX55

Q8NHQ9

DDX55

17.657

19.497

0.002

Down

KV133

P01593

IGKV1-33

20.221

21.109

0.016

Down

LEG10

Q05315

CLC

15.315

16.517

0.009

Down

OXSR1

O95747

OXSR1

12.997

14.154

0.002

Down

PICAL

Q13492

PICALM

20.039

21.127

0.042

Down

PTGDS

P41222

PTGDS

17.964

18.867

0.045

Down

S100A8

P05109

S100A8

21.790

22.381

0.044

Down

  1. Differentially expressed proteins (DEPs) are defined as those proteins with a fold change (FC) > 1.5 or FC < 1/1.5 and p < 0.05 between the responders and non-responders. Upregulated proteins in the responders compared with that in the non-responders, fold change (FC) > 1.5 and p < 0.05. Downregulated proteins in the responders compared with that in the non-responders, FC < 1/1.5 and p < 0.05. Words highlighted in bold indicate that the five proteins identified in the final logistic regression model