Fig. 1

Mixed ADSCs and SDSCs treatments promoted cartilage tissue formation and proliferation of chondrocytes. A schematic diagram of the combined MSCs treatment for chondrocyte. B schematic illustration of chondrocyte pellet cocultured with mixed ADSCs and SDSCs. C the chondrocyte pellet of gross view and quantitative analysis of diameter (D). E Safranin O staining, F Alcian blue staining, G Col2 immunohistochemical staining for pellet and H quantitative analysis of the Col2-positive cells. I, evaluation of the proliferation of chondrocytes by Ki67 and J the proportion of Ki67 positive cells. (TKA, total knee replacement; CC, chondrocyte; ADSC, adipose-derived stem cells; SDSC, synovium-derived stem cells. All data are shown as the mean ± SD. n = 3 or 4)