Fig. 4

Equally combined ADSCs and SDSCs alleviated cartilage degeneration and synovial inflammation of early and advanced OA. A schematic illustration of intra-injection of ADSCs and SDSCs for OA therapy. B H&E staining and C hyaline cartilage thickness was evaluated. D Safranin O–Fast Green staining and E OARSI scores (n = 4). F immunohistochemistry staining of Col2 and  G analysis of the proportion of positive area of Col2 (n = 3). H immunohistochemistry staining of MMP13 and I analysis of the proportion of MMP13 positive cell (n = 3). J H&E staining and  K synovial inflammation scores (n = 4). L immunohistochemistry staining of IL-1β and M analysis of the proportion of IL-1β positive cell (n = 3)