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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Distinct muscle regenerative capacity of human induced pluripotent stem cell-derived mesenchymal stromal cells in Ullrich congenital muscular dystrophy model mice

Fig. 5

Effect of MSCs on myogenesis in co-culture experiments. a Representative immunofluorescence images of Col6a1-KO/NSG mouse-derived MuSCs 3 days after single culture or co-culture with Ad-MSCs, BM-MSCs, or XF-iMSCs. b Total Number of DAPI + /hLamin A/C- mouse myogenic cells 3 days after co-culture. Data are expressed relative to XF-iMSCs and are presented as the mean ± SD of three independent experiments. c Percentage of Pax7 + /MyoD-, Pax7 + /MyoD + , and Pax7-/MyoD + cell populations 3 days after co-culture. Data from three independent experiments are shown as the mean ± SD. d Representative immunofluorescence images of Col6a1-KO/NSG mouse-derived MuSCs 6 days after single culture or co-culture with Ad-MSCs, BM-MSCs, or XF-iMSCs. e,f Area of MHC + myotubes (e) and number of MHC + myotubes with four or more nuclei (f) 6 days after co-culture. Data are expressed relative to XF-iMSCs and are presented as the mean ± SD of three independent experiments. *p < 0.05. n = 6(Ad-MSCs, BM-MSCs and XF-iMSCs), n = 3 (single culture)

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Stem Cell Research & Therapy

ISSN: 1757-6512