Fig. 1

The effect of different sources of MSCs in reducing inflammation and preventing endothelial-epithelial barrier damage. a Survival of animals following LPS induced ARDS with and without MSC-therapy. Data is represented as the percentage survival. b Levels of serum surfactant protein D (SP-D), 48 h after LPS injection. Data is represented as the mean ± SEM. *p < 0.05, ***p < 0.001; Kruskal–Wallis test, followed by 2-stage linear step-up procedure of Benjamini, Krieger, and Yekutietli for pairwise comparison. Each point represents an independent animal. c apoptosis of A549 cells (n = 5) following 48 h exposure to an inflammatory cocktail (TNF-α: 50 ng/ml and IFN-γ: 100 ng/ml). Data is represented as the min to max plot (n = 5). *p < 0.05, **p < 0.01; Kruskal–Wallis test. d Representative histology images (H&E staining: red triangle = alveolar thickening; star = inflammatory cells/neutrophil infiltration in the interstitial spaces; arrow = inflammatory cells/neutrophil infiltration in alveolar air spaces). Scale Bar = 250 μm (10x); 50 μm (40x); 25 μm (80x)