Fig. 1

HUCMSCs improved phenotype of mental and physical healthiness in SAMP8 Mice. A Schematic diagram of experimental design B New Object recognition test (n = 8 per group). C Rotarod test was applied to analyze drop time and drop speed (n = 7 per group). D Elevated plus maze was applied to analyze time in zone and entries in zone between group, and the percentage of entries in open arm and the percentage of time in open arm(n = 7 per group). E The body weight wew measured twice a week (n = 8–15 per group). F Genome-wide analysis of DNA single-strand breaks (SSBs) in different experimental groups. The bar graphs show the SSB levels in the whole genome, exonic regions, and within 200 bp of transcription start sites (TSS) for the P8_P, R1_P, and P8_M groups (n = 6 ~ 7 per group). G Gene clusters with the top 20 KEGG and Reactome pathways. The KEGG pathways of Exon_1 only returned 13 terms. All data shown as mean ± SD. Data were analyzed using one-way ANOVA followed by Tukey's post-hoc test in subfigure B-D and F. Abbreviation: R1_P: SAMR1_PBS; P8_P: SAMP8_PBS; and P8_M: SAMP8_MSC