Fig. 3

a Representative raster plots and respective cumulative instantaneous firing rate profiles (bin = 10 ms, overlapped) of the electrophysiological activity of the 100E (red) and 75E25I (orange) configurations in spontaneous conditions (first column) and after APV (second column), CNQX (third column), and BIC (fourth column) administration. A black dot represents a detected spike, while a dense black band indicates a network burst event. b-g Network bursting activity characterization during the chemical modulation. Normalized Network Bursting Rate (NBR) of 100E (red) and 75E25I (orange) configurations when APV (b, e), CNQX (c, f), or BIC (d, g) were used. The timepoint “Spont” represents the normalized NBR computed over the 10-min recording of the spontaneous activity. Data are represented with the mean (dot) and the standard error of the mean (whiskers) (∗ refers to p < 0.05 and ∗ ∗ to p < 0.01)