Fig. 4

Drugs' effect in the 10–15 min after the administration. a Plot of the normalized number of network bursting (NB) units for 100E (red) and 75E25I (orange) configurations. b Box plots of the normalized Network Bursting Rate (NBR) for each configuration. c, d Average network burst shapes (Spike Time Histogram, STH) for the spontaneous (grey) and the BIC-modulated activity for the 100E (c, red) and 75E25I (d, orange) configurations. Inset: box plots of the Network Burst Duration (NBD) for each configuration in spontaneous (grey) and BIC modulated (red or orange) conditions. Scatter plots are represented with the mean (dot) and the standard error of the mean (whiskers). Box plots are represented with the percentile 25–75 (box), the standard deviation (whiskers), the median (line), the mean (square), and the minimum and maximum (crosses) values (∗ refers to p < 0.05)