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Table 4 Comparison of median uptake readings of Tc-99 m ECD brain perfusion SPECT study before (baseline) and after (by 6-month) CD34 + cell therapy in both groups of patients

From: Long term outcomes of intracarotid arterial transfusion of circulatory-derived autologous CD34 + cells for acute ischemic stroke patients—A randomized, open-label, controlled phase II clinical trial

Variables

Median (Q1, Q3)■ (baseline) in cell-treated group

Median (Q1, Q3)■ (6 month) in cell-treated group

p-value*

Median (Q1, Q3) (baseline) in control group

Median (Q1, Q3) (6 month) in control group

p value*

Basal ganglia (L)

321.5 (263.8, 411.8)

326.5 (278.2, 384.7)

0.507

346.5 (275.5, 361.5)

303.1 (278.2, 359.2)

0.477

Basal ganglia (R)

333.5 (277.2, 465.1)

376.3 (250.4, 485.4)

0.807

354.3 (264.6, 410.8)

402.8 (333.7, 458.0)

0.110

Central region (L)

311.7 (244.6, 392.2)

325.9 (299.3, 401.6)

0.753

307.3 (274.7, 328.6)

291.1 (270.3, 334.5)

0.374

Central region (R)

317.5 (258.8, 442.5)

351.7 (322.0, 446.7)

0.753

329.1 (271.9, 367.3)

367.5 (295.0, 415.9)

0.130

Cerebellum (L)

355.7 (288.8, 477.7)

392.7 (310.9, 546.6)

0.463

355.6 (302.5, 392.9)

423.6 (341.4, 544.5)

0.110

Cerebellum (R)

343.3 (258.3, 446.2)

360.7 (280.4, 479.4)

0.552

317.7 (286.4, 372.1)

391.6 (329.9, 446.9)

0.110

Cingulate & paracingulate gyri (L)

336.1 (270.1, 422.8)

353.2 (296.4, 437.2)

0.861

305.1 (267.3, 374.5)

355.2 (307.6, 410.5)

0.286

Cingulate & paracingulate gyri (R)

322.4 (248.6, 427.5)

343.6 (291.1, 417.5)

0.753

323.4 (275.3, 343.6)

353.4 (300.6, 415.3)

0.213

Frontal lobe (L)

321.9 (250.3, 396.6)

325.3 (296.5, 412.0)

0.972

326.0 (262.9, 362.1)

333.3 (294.6, 375.8)

0.182

Frontal lobe (R)

303.7 (248.8, 426.9)

333.5 (294.3, 428.1)

0.753

299.4 (227.1, 321.4)

342.4 (308.6, 412.5)

0.131

Mesial temporal lobe (L)

293.4 (228.3, 388.3)

306.5 (233.0, 360.2)

0.753

305.1 (249.0, 351.8)

284.1 (254.7, 334.8)

0.286

Mesial temporal lobe (R)

299.7 (248.0, 395.9)

324.1 (286.5, 413.9)

0.807

357.8 (331.5, 391.8)

360.8 (289.0, 384.6)

0.131

Occipital lobe (L)

372.0 (307.9, 485.0) 

410.7 (326.4, 486.1)

0.701

363.5 (304.8, 422.2) 

379.5 (323.4, 476.3) 

0.182 

Occipital lobe (R)

362.6 (300.1, 504.0) 

415.9 (372.8, 509.3) 

0.6

320.1 (290.2, 348.9) 

415.3 (328.2, 484.9) 

0.110 

Parietal lobe (L)

343.4 (274.0, 399.5)

346.0 (322.4, 418.2)

0.861

330.1 (281.4, 380.8)

311.2 (283.0, 385.2)

0.182

Parietal lobe (R)

333.9 (280.0, 466.9)

378.0 (330.1, 468.3)

0.701

332.4 (274.8, 369.6)

388.9 (301.3, 425.6)

0.110

Temporal lobe (L)

336.1 (272.0, 389.9)

344.9 (268.9, 412.5)

0.701

364.5 (287.2, 397.6)

315.9 (269.8, 372.2)

0.328

Temporal lobe (R)

333.8 (281.0, 477.6)

384.9 (341.7, 481.4)

0.701

378.6 (328.9, 468.7)

394.6 (324.1, 460.5)

0.110

  1. L left, R right, M month, SD standard deviation
  2. ■ Indicates patients were treated with CD34 + cells
  3. *Indicates statistical analysis via the Wilcoxon signed-rank test for paired data