Fig. 5

N-CADHERIN⁺/CD168⁻ Cell Subpopulation Have Beneficial Effects on Cardiac Function of MI Mice. (A and B) Representative images depicting the percentage of N-CADHERIN⁺/CD168⁻ subpopulation in the UC-MSCs from different donors (A), with quantitative analysis of percentages of cells (B). **P < 0.01, ***P < 0.001 versus MSC-CX. (C) Pearson correlation analysis of EF and FS with the percentage of N-CADHERIN⁺/CD168⁻ cells. (D) Echocardiography analysis of EF and FS in MI (Ctrl), MI + N-CADHERIN⁺/CD168⁻ from MSC-GY (N-CAD⁺/CD168⁻-GY), MI + MSC-GY depleted of N-CADHERIN⁺/CD168⁻ subpopulation (Others-GY), and MI + N-CADHERIN⁺/CD168⁻ from MSC-CX (N-CAD⁺/CD168⁻-CX) groups at 4 weeks post-MI (n = 6). ns, **P < 0.01, versus Ctrl. (E) Representative images of masson trichrome staining of heart sections at 4 weeks post-MI. Scale bar: 500 μm. (F) Quantification of infarct size at 4 weeks post-MI. ns, **P < 0.01, versus Ctrl. (G) Ranked results of the DEGs in the N-CADHERIN ⁺/CD168⁻ subpopulation. (H) Prediction of transcription factors (TFs) for the N-CADHERIN⁺/CD168⁻ subpopulation. Statistical significance was determined using one-way ANOVA followed by Tukey’s post hoc