Fig. 1

Multifactorial based identification of combined ADRC- and lipoaspirate intervention responders and non-responders using clinical outcomes. A For all 39 BCRL patients receiving combined treatment with ADRC and lipoaspirate, the 12-month change versus baseline data for clinical outcomes (volumetric, quality of life, cellulitis, indocyanine green lymphangiography (ICG-L) and compression outcomes) are mapped by hierarchical clustering. B Avoiding repetitive clustered clinical outcomes in A remaining data analyzed by Principal Component Analysis (PCA) are shown in C, D with listing of PCA drivers. E–G The clinical outcome data for the main PCA drivers (SF-36 Physical Change, ICG Distance Change, and Idex Lymphedema change) are used to arrange patients according to effect for each parameter. H Indication of intervention responders and non-responders based on the PCA drivers in E–G