Fig. 2

Comparative analysis of ADRCs from reponders and non-responders. A–C The number, size and viability of ADRCs injected into responders (blue) and non-responders (red). D Single Cell RNA sequencing quality metrics of ADRCs from responders and non-responders fetched from output of CellRanger pipeline. E Low-dimensional UMAP embedding of single cells grouped by cell type based on marker gene expression according to F. G UMAP distribution and H, quantification of the percentage of ADRCs within each UMAP cluster between responders and non-responders. I Flow cytometry of ADRCs for quantification of the percentage of hematopoietic-, endothelial-, and stem cell populations between responders and non-responders. For A–C and I, data represent the median and interquartile range with indication of each datapoint. Statistical differences between responders and non-responders A–C, H–I were determined by non-parametric Mann Whitney testing (α < 0.05)