Fig. 4
Effects of cell size on hUC-MSCs distribution in BALB/c mice. (A) Representative PET images of BALB/c mice injected with 89Zr-labeled hUC-MSCs derived from 2D monolayers and 3D spheroids at various time point within 48 h. (B) Lung uptake of the 89Zr-labeled hUC-MSCs based on the PET imaging (n = 4). (C) Ex vivo biodistribution of intravenously transplanted 89Zr-labeled hUC-MSCs in BALB/c mice (n = 4). Values are expressed as the means ± SD. *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001; ns, not significant, p > 0.05