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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Hematopoietic stem cell heterogeneity and age-related platelet bias: implications for bone marrow transplantation and blood disorders

Fig. 1

Age-Related Dynamic Changes in Hematopoietic Stem Cells and Their Impact on Blood Homeostasis and Immune Function. Recent research has highlighted the complexity of hematopoietic stem cells (HSCs), particularly the emergence of platelet-biased HSCs (P-HSCs) with age. The proportion of P-HSCs increases with age, accompanied by enhanced platelet priming in their transcriptional profiles, which may disrupt blood homeostasis. This age-related shift is also associated with a decline in multilineage HSCs (ML-HSCs), contributing to diminished adaptive immune function in the elderly. The expansion of P-HSCs may lead to hematopoietic aging and the onset of conditions like essential thrombocythemia. These findings have broad implications for bone marrow transplantation, hematopoietic regeneration, and the development of hematological malignancies

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Stem Cell Research & Therapy

ISSN: 1757-6512