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Table 1 MSC-EXOs-related miRNAs for the treatment of liver diseases

From: Advances in the treatment of liver injury based on mesenchymal stem cell-derived exosomes

Diseases

MiRNA

Model

Mechanism

Liver fibrosis

miR-27b-3p

CCl4-induced mouse model

Inhibit LOXL2 as the downstream target gene of YAP [63]

Liver fibrosis

miR-148a

CCl4-induced mouse model

Target KLF6 to control the STAT3 signaling pathway [64]

Liver fibrosis

miR-125b

CCl4-induced mouse model

Inhibiting Smo expression and Hh signaling activation [65]

Liver fibrosis

miR-122

CCl4-induced mouse model

Targeting the binding site located in the 3'-UTR of P4HA1 mRNA [66]

Liver fibrosis

miR-181-5p

CCl4-induced mouse model

Inhibit STAT3/Bcl-2/ Beclin-1 pathway [67]

ALF

miR-455-3p

CCl4/LPS-induced mouse model

Inhibit inflammatory responses by targeting PIK3r1 [68]

HCC

miR-199a-3p

Orthotopic HCC mouse model

Reversed the reduced phosphorylation of 4EBP1 and 70S6K in HCC cells and the reduced chemoresistance of HCC cells treated [69]

HCC

miR-451a

human HCC cell lines Hep3B, MHCC-97 H, HB611, HepG2 and SMMC-7721

Delay the progression of EMT by inhibiting ADAM10 [70]

HCC

miR-15a

human HCC cell lines Hep3B and Huh7

Downregulation of SALL4 inhibits the proliferation, migration and invasion of HCC cells [71]

HCC

miR-122

HepG2 cell xenograft model

Enhance the chemosensitivity of HCC [72]

Liver oxidative stress

miR-26a-5p

cecal ligation puncture (CLP) and lipopolysaccharide (LPS) plus D-galactosamine (D-gal) as sepsis-induced ALI model

Targeting MALAT1 reduces oxidative stress [73]

Liver oxidative stress

miR-200a

DEN-induced LF model

Preventing oxidative stress, inflammation, necroptosis and anti-fibrosis [74]

Liver steatosis

miR-96-5p

HFD-induced mouse model

Inhibits caspase-2, thereby hindering fatty acid synthesis and lipid uptake, and upregulates fatty acid oxidation [75]

Liver steatosis

miR-627-5p

HFHF-induced mouse model

Enhanced lipid and glucose metabolism and decreased liver damage by blocking FTO expression [76]