Table 2 Application of MSC-EXOs in liver regeneration
From: Advances in the treatment of liver injury based on mesenchymal stem cell-derived exosomes
Source | miRNA | Model | Mechanism |
|---|---|---|---|
hESC | Unknown | CCl4-induced mouse model | Increased the expression of NF-κB and STAT3 transcription factors and initiated liver regeneration by activating NF-κB and IL-6 dependent pathways [144]. |
hypoxic MSC | miR-182-5p | PHx mouse model | Regulated the forkhead box transcription factor 1 (FOXO1)/toll-like receptor 4 (TLR4) signaling pathway to enhance macrophage polarization during liver regeneration [145]. |
CP-MSC | miR-125b | CCl4-induced mouse model | Regulates the expression of the Hh signaling pathway, promotes fibrosis regression, and ultimately promotes liver regeneration [65]. |
hucbMSC | miR-124 | PHx mouse model | Promote liver regeneration after PHx in rats by down-regulating the transcription Foxg1 [146]. |
PD-MSC | unknown | BDL rat model | Upregulate CRP and promote angiogenesis by activating the Wnt pathway, and play a direct role in liver regeneration of hepatocytes [149]. |