Fig. 5

Fertility restoration by HF-MSCs transplantation in mice with CTX-induced POF. Reproductive outcomes in four mating experiments with fertile males. Mating occurred 2 weeks after the last HF-MSCs transplantation. A F1 pups from mice in the CON, POF, P–H and P–U groups. B Mean litter size per pregnant mouse for generation F1 (n = 5). Data represent mean ± SD, *: p < 0.05, **: p < 0.01, and ns: no significance