Fig. 5
Source data are available in the Source Data file
Relation between SERS metabolic profiling and RNA expression. a t-SNE visualization of the 19 most significantly changed genes. b Pearson’s correlation coefficient between the RNA expression and the SERS spectral intensities (left) as well as the metabolite coefficients (right). The mean spectrum of all lysate SERS spectra is displayed with the characteristic peaks of the metabolites pointed by colored arrows for clarity. The correlation between RNA expressions and metabolite coefficients with |PCC|> 0.8 and p < 0.01 are exhibited by thick black boxes and c displayed in detail by scatter plots with the different cell generations labeled by dashed circles.