Table 2 Cellular
Placebo | |||||||||
Visit 1 | SEM V1 | Visit 3 | SEM V3 | P value(V1,V3) | |||||
Migration assay | 0.54 | 0.00 | 0.25 | 0.07 | 0.14 | ||||
CFU | 9.70 | 1.28 | 4.13 | 0.45 | 0.11 | ||||
CAT | 1.10 | 0.51 | 1.86 | 1.74 | 0.22 | ||||
CXCL12 | 1.26 | 1.01 | 5.23 | 8.52 | 0.23 | ||||
CXCR4 | 1.78 | 1.84 | 1.61 | 1.85 | 0.45 | ||||
EDN1 | 1.11 | 0.50 | 1.01 | 0.22 | 0.41 | ||||
GPX3 | 2.20 | 2.51 | 4.36 | 6.00 | 0.27 | ||||
IL6 | 1.27 | 0.97 | 1.42 | 1.42 | 0.44 | ||||
KDR | 1.49 | 1.59 | 1.34 | 1.25 | 0.46 | ||||
NOS3 | 1.03 | 0.26 | 1.06 | 0.49 | 0.46 | ||||
P21 | 1.12 | 0.69 | 1.26 | 1.13 | 0.44 | ||||
PECAM1 | 2.18 | 2.98 | 1.56 | 1.38 | 0.36 | ||||
SOD2 | 1.04 | 0.37 | 1.71 | 2.26 | 0.29 | ||||
TNF | 2.96 | 4.41 | 2.20 | 3.08 | 0.40 | ||||
TP53 | 1.17 | 0.70 | 2.00 | 1.93 | 0.26 | ||||
VEGFA | 2.47 | 3.88 | 1.96 | 2.20 | 0.42 | ||||
CD34-FITC | 3.55 | 0.29 | 1.74 | 0.31 | 0.16 | ||||
CD184-APC | 73.40 | 68.37 | 3.44 | ||||||
CD31-FITC | 63.70 | 6.06 | 60.68 | 6.86 | 0.47 | ||||
CD34+CD184+ | 2.38 | 0.49 | 20.11 | 6.05 | 0.28 | ||||
CD31+CD184+ | 66.10 | 63.28 | 2.85 | ||||||
Nephrin/CD9 | 0.55 | 0.11 | 0.67 | 0.13 | 0.43 | ||||
PODXL/CD9 | 3.13 | 0.70 | 0.80 | 0.01 | 0.26 | ||||
Dapagliflozin | |||||||||
Visit 1 | SEM V1 | Visit 3 | SEM V3 | P value(V1, V3) | |||||
Migration assay | 0.53 | 0.05 | 0.68 | 0.03 | 0.12 | ||||
CFU | 18.88 | 6.71 | 5.33 | 1.09 | 0.22 | ||||
CAT | 1.43 | 1.28 | 1.42 | 1.20 | 0.50 | ||||
CXCL12 | 1.01 | 0.22 | 15.95 | 26.74 | 0.19 | ||||
CXCR4 | 1.13 | 0.56 | 1.31 | 0.90 | 0.37 | ||||
EDN1 | 1.14 | 0.65 | 1.93 | 2.00 | 0.24 | ||||
GPX3 | 1.13 | 0.70 | 1.52 | 1.25 | 0.31 | ||||
IL6 | 1.22 | 0.88 | 1.01 | 0.16 | 0.35 | ||||
KDR | 1.18 | 0.62 | 1.89 | 1.86 | 0.25 | ||||
NOS3 | 1.12 | 0.59 | 1.72 | 2.13 | 0.30 | ||||
P21 | 1.24 | 0.97 | 1.48 | 1.14 | 0.38 | ||||
PECAM1 | 1.36 | 0.97 | 1.35 | 0.99 | 0.49 | ||||
SOD2 | 1.05 | 0.42 | 1.07 | 0.41 | 0.47 | ||||
TNF | 1.85 | 1.27 | 1.19 | 0.71 | 0.20 | ||||
TP53 | 1.47 | 1.46 | 1.59 | 1.27 | 0.45 | ||||
VEGFA | 1.29 | 1.09 | 1.31 | 0.97 | 0.49 | ||||
CD34-FITC | 0.61 | 0.19 | 1.15 | 0.33 | 0.34 | ||||
CD184-APC | 63.85 | 7.73 | 58.40 | 7.78 | 0.44 | ||||
CD31-FITC | 87.35 | 3.24 | 69.00 | 10.29 | 0.30 | ||||
CD34+CD184+ | 0.65 | 0.20 | 1.00 | 0.30 | 0.38 | ||||
CD31+CD184+ | 55.30 | 3.71 | 56.00 | 10.64 | 0.49 | ||||
Nephrin/CD9 | 1.64 | 0.04 | 1.16 | 0.10 | 0.12 | ||||
PODXL/CD9 | 3.30 | 0.22 | 2.59 | 0.43 | 0.33 | ||||
Combination | |||||||||
Visit 1 | SEM V1 | Visit 3 | SEM V3 | P value(V1, V3) | |||||
Migration assay | 0.38 | 0.10 | 0.75 | 0.02 | 0.13 | ||||
CFU | 12.63 | 1.39 | 9.70 | 2.32 | 0.34 | ||||
CAT | 1.12 | 0.56 | 1.72 | 1.92 | 0.29 | ||||
CXCL12 | 1.02 | 0.25 | 1.01 | 0.17 | 0.49 | ||||
CXCR4 | 1.52 | 1.42 | 1.08 | 0.48 | 0.32 | ||||
EDN1 | 1.08 | 0.58 | 1.00 | 0.01 | 0.40 | ||||
GPX3 | 1.22 | 0.77 | 1.65 | 1.87 | 0.36 | ||||
IL6 | 1.91 | 1.62 | 1.03 | 0.32 | 0.20 | ||||
KDR | 1.54 | 1.66 | 1.04 | 0.40 | 0.36 | ||||
NOS3 | 1.19 | 0.87 | 1.20 | 0.86 | 0.49 | ||||
P21 | 1.28 | 1.02 | 1.38 | 1.30 | 0.45 | ||||
PECAM1 | 1.50 | 1.63 | 1.21 | 0.79 | 0.38 | ||||
SOD2 | 1.23 | 0.93 | 1.24 | 0.98 | 0.49 | ||||
TNF | 1.48 | 1.52 | 1.10 | 0.58 | 0.35 | ||||
TP53 | 1.47 | 1.38 | 1.31 | 1.03 | 0.44 | ||||
VEGFA | 5.34 | 9.53 | 1.22 | 0.74 | 0.25 | ||||
CD34-FITC | 2.35 | 0.36 | 3.17 | 0.28 | 0.22 | ||||
CD184-APC | 54.78 | 6.18 | 62.78 | 4.85 | 0.34 | ||||
CD31-FITC | 63.34 | 6.11 | 81.94 | 5.49 | 0.17 | ||||
CD34+CD184+ | 1.92 | 0.29 | 3.08 | 0.15 | 0.08 | ||||
CD31+CD184+ | 39.10 | 5.83 | 51.62 | 5.64 | 0.27 | ||||
Nephrin/CD9 | 0.66 | 0.49 | 0.10 | ||||||
PODXL/CD9 | 2.77 | 2.10 | 0.48 | ||||||