Fig. 4

Macroscopic analysis and micro-computed tomography (micro-CT) scans of sheep tibial plateau. (A) Macroscopic analysis of tibial plateaus in normal sheep and sheep who underwent knee osteoarthritis surgically induced by anterior cruciate ligament transection and medial meniscectomy, followed by intra-articular injections of sterile saline (NC) or haMSCs into the right knee joint at 6 weeks (one dose) and 9 weeks (one dose) after surgery. (B) Micro-CT scans of the tibial plateau in experimental and control groups. (C) Measurement of cartilage thickness in the tibial plateau of the experimental and control groups (three animals per group). Abbreviations: NC, negative control; haMSCs, human adipose-derived mesenchymal stem cells; NS, not significant