Fig. 3

Bulk transcriptome changes of ADSCs and CX₃CR1⁺ lining macrophages after co-culture. (A) Cell viability difference between separately cultured and direct co-cultured cells after 96 h at 1:1 ratio. (B) GO analysis of upregulated genes in co-cultured ADSCs vs. separately cultured ADSCs (log2FC > 1, Padj < 0.05). (C) GO analysis of upregulated genes of co-cultured CX₃CR1⁺ lining macrophages vs. individually cultured CX₃CR1⁺ lining macrophages (log2FC > 1, Padj < 0.05). (D) CellChat chord diagram of cell-cell communication between ADSCs and CX₃CR1⁺ lining macrophages based on the bulk RNA-seq data (Padj < 0.05)