Fig. 6

Nano CT analysis of medial subchondral bone plate thickness (SCBP) and the medial and lateral condyle length. (A) Quantification of the SCBP thickness in the control (PBS and rBMSC-lacZ) and the rBMSC-αCGRP- and–SP groups, 8 or 16 weeks after the DMM or sham surgery. Image on the right shows the representative image of the tibial plateau with the corresponding ROI marked by * and red bars. (B) Diagram of the medial condyle length and C) of the lateral condyle length in the different treatment groups, 8 or 16 weeks after the DMM or sham surgery. Representative µCT images display the tibial plateau, as well as an representatively measured condyle length. Generalized Linear Model (GLM); n (total) = 48; N (per group) = 3; *p ≤ 0.05; **p ≤ 0.01