Table 2 OARSI guidelines for assessment of murine cartilage degradation

0

Normal

0,5

Loss of Safranin O staining without structural changes

1

Small fibrillations without loss of cartilage / uneven surface

2

Vertical clefts and erosions down to the layer immediately below the superficial layer and some loss of surface lamina

3

Vertical clefts / erosions to the calcified cartilage < 25% of the articular surface

4

Vertical clefts / erosions to the calcified cartilage 25–50% of the articular surface

5

Vertical clefts / erosions to the calcified cartilage 50–75% of the articular surface

6

Vertical clefts / erosions to the calcified cartilage > 75% of the articular surface