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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Paracrine activity of Smurf1-silenced mesenchymal stem cells enhances bone regeneration and reduces bone loss in postmenopausal osteoporosis

Fig. 6

MicroCT analysis of the osteo-regenerative effect of the local intraosseous administration of the CM-Smurf1 in a post-menopausal osteoporotic mouse model. (A) Experiment outline, (B) representative micro-CT coronal and trans-axial images femurs from Non-Ovariectomized mice (No-OVX), OVX mice treated with NaCl (NaCl), OVX mice treated with the CM-Ctrl (CM-Ctrl) and OVX mice treated with CM-Smurf1 (CM-Smurf1), (C) bone volume/tissue volume (BV/TV; %), trabecular number (Tb.N), trabecular thickness (Tb.Th) and space between trabecula were analyzed by using a Quantum GX micro-CT imaging system (PerkinElmer). Results are presented as means ± SEM (n = 5).*: p-value < 0.05; **: p -value < 0.01

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Stem Cell Research & Therapy

ISSN: 1757-6512