Fig. 1
From: Unraveling the function of TSC1-TSC2 complex: implications for stem cell fate
Basic structure and biology function of TSC1 (hamartin), TSC2 (tuberin) and TSC1D7. (A). Structure of TSC1 (hamartin), TSC2 (tuberin) and TSC1D7. Only inhibitory phosphorylation sites are shown. (a) Structure of TSC1 and inhibitory phosphorylation sites with GS3K and CDK1. (b) Structure of TBC1D7. (c) Structure of TSC2 and inhibitory phosphorylation sites with ERK2, AKT MK2, AMPK and RSK1. (B). TSC1, TSC2, and TBC1D7 form a TSC1-TSC2 complex that regulates mTORC1. TSC1-TSC2 complex acts as a signal integration to maintain intracellular homeostasis. Only major regulators and targets are shown