Table 2 The role of TSC1 and TSC2 in regulating stem cell behaviors
From: Unraveling the function of TSC1-TSC2 complex: implications for stem cell fate
Protein | Cell type | Species | Effects | Mechanisms | References |
|---|---|---|---|---|---|
TSC1 | eNPCs | Mouse | Maintenance | mTORC1 | [58] |
TSC2 | NSCs | Human | Proliferation | mTORC1, PAX6 | [102] |
TSC1 | eNPCs | Mouse | Migration and neuronal differentiation | mTOR- S6K | [103] |
TSC1 | eNSCs | Mouse | Maintenance and differentiation inhibition | mTORC1, STAT3 | [57] |
TSC1 | GSCs | Drosophila | Maintenance and differentiation inhibition | mTORC1-S6K | [69] |
TSC2 | GSCs | Drosophila | Maintenance and differentiation inhibition | mTORC1-S6K | [69] |
TSC2 | SPCs | Mouse | Heterogeneity and differentiation | mTORC1 | [70] |
TSC1 | NPCs | Mouse | Migration | [62] | |
TSC1 | NPCs | Mouse | Migration | mTORC1 TFEB | [63] |
TSC1 | Nephron progenitor cells | Mouse | Proliferation | Raptor | [74] |
TSC1 | Nephron progenitor cells | Mouse | Proliferation | mTORC1 | [75] |
TSC1 | Nephron progenitor cells | Mouse | Proliferation | Wnt signal | [73] |
TSC1 | ISC | Drosophila | Maintenance and differentiation | mTORC1-S6K | [104] |
TSC2 | ISC | Drosophila | Maintenance and differentiation | mTORC1 | [80] |
TSC2 | ISC | Mouse | Maintenance | mTORC1, FZD | [79] |
TSC1 | HSCs | Mouse | Maintenance | ROS production | [83] |
TSC1 | HSCs | Mouse | Mobilization, proliferation and differentiation. | mTORC1 | [82] |
TSC1 | MSCs | Mouse | Proliferation and differentiation | mTORC1 | [90] |
TSC1 | BM-MSC | Mouse | Maintenance and proliferation | mTORC1 | [91] |