Circadian rhythms in stem cells and their therapeutic potential

Table 3 Circadian synchronizors in stem cells

Intervention	Cell model	Cycle length (hours)	Outcomes	References
Dexamethasone	Mouse/human BM-MSCs	24	Oscillating clock gene expression	[78]
	Human iPSCs	24	DBP rhythm but not BMAL1/PER2, more likely from temperature rhythm	[79]
	Human ASCs, BM-MSCs, dental pulp stem cells (DPSCs)	12–24	Oscillating clock gene expression	[80]
Forskolin	Human iPSCs	24	DBP rhythm but not BMAL1/PER2, more likely from temperature rhythm	[79]
cAMP	Human MSCs	20–24	Oscillating clock gene expression	[44]
Serum shock	Human MSCs	20–24	Oscillating clock gene expression	[44]
Fasting	Human MSCs	24	Increased amplitude of clock gene oscillation	[48]

ISSN: 1757-6512