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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: MSC-exosomes pretreated by Danshensu extracts pretreating to target the hsa-miR-27a-5p and STAT3-SHANK2 to enhanced antifibrotic therapy

Fig. 7

Mechanism diagram. Annotation: Specific miRNAs upregulated or downregulated by DSS-Exo include hsa-miR-126-3p_R-1, hsa-miR-223-3p, hsa-miR-122-5p_R-1, among others, which modulate genes related to fibrosis such as α-SMA, CTGF, E-cadherin, Fibronectin, VEGFA, and HIF-1α. DSS-Exo modulate the STAT3 transcription factor, which binds to the SHANK2 promoter, influencing gene transcription

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Stem Cell Research & Therapy

ISSN: 1757-6512