Fig. 2

Effects of hUC-MSCs on clinical score and pathological manifestations of NMOSD mice. (A) Clinical scores of NMOSD mice with PBS or hUC-MSC treatment (NMOSD + PBS, n = 5; NMOSD + MSC, n = 8). (B) HE staining images of the lumbar spinal cord from NMOSD mice with PBS or hUC-MSC treatment. Scale bar 100 μm. (C) LFB staining images of the lumbar spinal cord from NMOSD mice with PBS or hUC-MSC treatment. Scale bar 100 μm. (D) Immunofluorescence images of MBP (green) in lumbar spinal cord from NMOSD mice with PBS or hUC-MSC treatment. Cell nuclei are labeled by DAPI staining (blue). Scale bar 200 μm. (E) The statistical analysis of inflammation scores for HE staining (NMOSD + PBS, n = 4; NMOSD + MSC, n = 5). (F, G) The statistical analysis of myelin loss area for LFB staining and MBP IF staining (NMOSD + PBS, n = 4; NMOSD + MSC, n = 5). (data = mean ± SEM, *represents a significant difference, *p < 0.05, **p < 0.01, ****p < 0.0001)