Table 2 Clinical trials in mitochondria transplantation for ischemic cardiomyocytes rehabilitation
Title | Case NO. | Identification number | Cell source for mitochondria | Dose and administration route | Results | Ref |
|---|---|---|---|---|---|---|
Autologous mitochondrial transplantation for cardiac ischemic injury | 5 patients | Not registered | Healthy rectus abdominis muscle | Intramyocardial injection of 1 × 108 ± 1 × 105 mitochondrial particles | Improved ventricular function | [58] |
Autologous mitochondrial transplantation in pediatric patients with cardiac tissue ischemia-reperfusion Injury | Pilot study on 24 patients | NCT02851758 | Autologous chest skeletal muscles | ND | ND | [116] |
Co-transplantation (intracoronary and intra-myocardial injection) of MSC exosomes and autologous mitochondria in patients subjected to CABG surgery | Phase I, II | NCT05669144 | Co-transplantation of autologous pectoralis muscle mitochondria and MSC exosomes | 100 µg/ml exosome containing 1 × 106 mitochondria | ND |  |
Platelet mitochondria in heart ischemia | Phase I, II | IRCT20210920052524N1 | Platelet mitochondria | Intracoronary | ND | Â |