Fig. 6
From: FBF1 maintains stem cell-like properties in breast cancer via PI3K/AKT/SOX2 axis
FBF1 enhances the CSCs-like features of breast cancer in vivo. (A-C) Ectopic FBF1 promotes tumor growth, which is rescued by PI3K inhibitor. (D-F) H&E staining is used for analysis of lung metastasis and the metastases were quantified (n = 5). Scale bars: 100 μm. (G, H) IHC staining of p-PI3K, p-AKT, E-cadherin, and stemness markers in tumor tissue sections and quantification (n = 5). Scale bars: 50 μm. (I) The tumor initiation ability of T47D cells were analyzed with limited dilution assay (n = 6). CI: confidence interval