Fig. 6
From: Retinal ganglion cells induce stem cell-derived neuroprotection via IL-12 to SCGF-β crosstalk
iPSC-derived SCGF-β promotes RGC survival via upregulation of ngn2. A-B RT-qPCR results showed a significant increase of ngn2 mRNA in RGCs cocultured with iPSCs or treated with SCGF-β. C-D Overexpression of ngn2 in RGCs cultured in the RGC medium for 1 week significantly increased RGC viability. E Knockdown of ngn2 in RGCs cultured for 1 week does not significantly alter RGC survival, whether treated with SCGF-β or not. *P < 0.05. Error bar denotes SD