The inconclusive superiority debate of allogeneic versus autologous MSCs in treating patients with HFrEF: a systematic review and meta-analysis of RCTs

Ahmed, Omar T. F.; Ahmed, Ziyad Tarek; Dairi, Abdulrahman W.; Zain Al-Abeden, Maha Saad; Alkahlot, Mohammed H.; Alkahlot, Rana H.; Al Jowf, Ghazi I.; Eijssen, Lars M. T.; Haider, Khawaja Husnain

doi:10.1186/s13287-025-04209-5

Stem Cell Research & Therapy

Table 1 Characteristic features of the thirteen RCTs included in the meta-analysis. Quality assessment (risk of bias) using the Jadad Score

From: The inconclusive superiority debate of allogeneic versus autologous MSCs in treating patients with HFrEF: a systematic review and meta-analysis of RCTs

Study	Arm	Source	Sampling site	Country	Etiology	Sample size	Males	Age	RoA	Imaging modality	F/U (mo)
MSC-HFT [19]	Intervention	Autologous	Bone marrow (Iliac crest)	Denmark	Ischemic HF	40	36	66.1 (7.7)	IM	MRI or CT	6
MSC-HFT [19]	Control	Autologous	Bone marrow (Iliac crest)	Denmark	Ischemic HF	20	14	64.2 (10.6)	IM	MRI or CT	6
CONCERT-HF [20]	Intervention	Autologous	Bone marrow	USA	Ischemic Cardiomyopathy	29	27	61.7 (6.7)	TE	MRI	12
CONCERT-HF [20]	Control	Autologous	Bone marrow	USA	Ischemic Cardiomyopathy	32	31	63.1 (8.8)	TE	MRI	12
Xiao et al. [21]	Intervention	Autologous	Bone marrow (Posterior iliac spines)	China	Dilated Cardiomyopathy	17	12	51.6 (12.2)	IC	Echo	12
Xiao et al. [21]	Control	Autologous	Bone marrow (Posterior iliac spines)	China	Dilated Cardiomyopathy	20	14	54.4 (11.6)	IC	Echo	12
TAC-HFT [22]	Intervention	Autologous	Bone marrow (Iliac crest)	USA	Ischemic Cardiomyopathy	22	18	57.1 (10.6)	TE	MRI or CT	12
TAC-HFT [22]	Control	Autologous	Bone marrow (Iliac crest)	USA	Ischemic Cardiomyopathy	22	10	60 (12.0)	TE	MRI or CT	12
Athena Trials [18]	Intervention	Autologous	Abdominal adipose tissue	USA	Ischemic Cardiomyopathy	17	16	64.1 (8.2)	IM	Echo	6
Athena Trials [18]	Control	Autologous	Abdominal adipose tissue	USA	Ischemic Cardiomyopathy	14	13	65.7 (7.3)	IM	Echo	6
PRECISE Trial [23]	Intervention	Autologous	Abdominal adipose tissue	USA	Ischemic Cardiomyopathy	21	17	65.8 (6.3)	TE	Echo	36
PRECISE Trial [23]	Control	Autologous	Abdominal adipose tissue	USA	Ischemic Cardiomyopathy	6	4	55.7 (6.1)	TE	Echo	36
RIMECARD Trial [24]	Intervention	Allogeneic	Umbilical cord	Chile	Ischemic or Nonischemic Cardiomyopathy	15	12	57.33 (10.05)	IV	Echo	12
RIMECARD Trial [24]	Control	Allogeneic	Umbilical cord	Chile	Ischemic or Nonischemic Cardiomyopathy	15	14	57.20 (11.64)	IV	Echo	12
Danish phase II [25, 26]	Intervention	Allogeneic	Abdominal adipose tissue	Denmark	Ischemic HF	54	44	67.0 (9.0)	IM	Echo	6/12
Danish phase II [25, 26]	Control	Allogeneic	Abdominal adipose tissue	Denmark	Ischemic HF	27	24	66.6 (8.1)	IM	Echo	6/12
Butler et al. [27]	Intervention	Allogeneic	Bone marrow	USA	Nonischemic Cardiomyopathy	12	13	47.3 (12.8)	IV	MRI	3
Butler et al. [27]	Control	Allogeneic	Bone marrow	USA	Nonischemic Cardiomyopathy	12	13	47.3 (12.8)	IV	MRI	3
Perin et al. [28]	Intervention	Allogeneic	Bone marrow (Posterior iliac crest)	USA	Ischemic or Nonischemic HF	45	2	60.1 (8.8)	TE	Echo	12
Perin et al. [28]	Control	Allogeneic	Bone marrow (Posterior iliac crest)	USA	Ischemic or Nonischemic HF	15	4	62.7 (11.2)	TE	Echo	12
Zhao et al. [29]	Intervention	Allogeneic	Umbilical cord	China	Ischemic or Nonischemic Cardiomyopathy	30	24	52 (16)	IC	Echo	6
Zhao et al. [29]	Control	Allogeneic	Umbilical cord	China	Ischemic or Nonischemic Cardiomyopathy	29	19	53 (11)	IC	Echo	6
SCIENCE [25, 26]	Intervention	Allogeneic	Abdominal adipose tissue	Denmark	Ischemic HF	90	84	66.4 (8.1)	IM	Echo	6/12
SCIENCE [25, 26]	Control	Allogeneic	Abdominal adipose tissue	Denmark	Ischemic HF	43	38	64.0 (8.8)	IM	Echo	6/12
DREAM-HF [30]	Intervention	Allogeneic	Bone marrow	Canada, USA	Ischemic or Nonischemic HF	265	222	62.7 (10.9)	TE	Echo	12
DREAM-HF [30]	Control	Allogeneic	Bone marrow	Canada, USA	Ischemic or Nonischemic HF	272	221	62.6 (10.4)	TE	Echo	12

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ISSN: 1757-6512

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