Table 3 Strategies for inducing skin organoids from PSCs
From: Functional regeneration strategies of hair follicles: advances and challenges
Organism | Cell | Induction strategy |
|---|---|---|
• Mice [64] | • Mouse ESCs • Mouse iPSCs generated from embryonic fibroblasts | Sequential application of SB/BMP and LDN/FGF |
• Human ESCs: WA25 [67] • Human iPSCs: nciPS02, RC01001-B [68, 69]; LUMCi045-A1 and LUMCi046-A1 [70] | SB/BMP-LDN/FGF strategy | |
• Human [71] | • Human iPSCs: CMC003 and CMC011 | SB/BMP-LDN/FGF/CHIR strategy and ALI culture |