Table 2 Characterization of MSC-ApoEVs
Source of MSCs | Diameter size | Apoptosis-specific surface marker | Specific protein markers in MSC-ApoEVs | Evs-related markers | MSCs-related markers | Reference |
|---|---|---|---|---|---|---|
hUCMSCs | average 300Â nm | PS, C1q | cleaved Caspase 3 | / | / | [64] |
185.2 ± 17.7 nm | PS | cleaved Caspase 3 | / | / | [65] | |
600–1200 nm | PS, PD-L1 | cleaved Caspase 3 | / | / | [66] | |
mBMMSCs | average 1000Â nm | C1q, PS | cleaved Caspase 3 | / | / | [67] |
average 150Â nm | PS, CRT | cleaved Caspase 3, cleaved lamin B1 | CD9, TSG101 | / | [68] | |
158.7 ± 13.5 nm | PS, C1q, CRT | cleaved Caspase 3, thrombospondin 1 | CD63, CD9, Flotillin1, Alix | / | [69] | |
average 1000Â nm | PS, | cleaved Caspase 3, Thrombospondin 1, BAX, HIF-1a | / | / | [38] | |
100–1000 nm | PS | cleaved Caspase 3 | TSG101, Flotillin-1 | / | [70] | |
average 159.2Â nm | Integrin alpha-5, CRT, Calnexin | / | / | / | [71] | |
100–200 nm | PS, CRT | cleaved Caspase 3, cleaved PARP1, cleaved Caspase 8 | / | / | [72] | |
100–200 nm | / | Thrombospondin 1 | CD63, CD81 | / | [73] | |
hBMMSCs | 150.1 ± 14.8 nm | Integrin alpha-5, Sphingosine 1-phosphate receptors 1, CRT, PS | cleaved Caspase 3 | CD9, CD63, TSG101, Alix | / | [74] |
199.3 ± 91.3 nm | PS, CRT, Fas, Integrin alpha-5 | / | CD9, CD63, CD81 | CD29(+), CD44(+), CD90(+), CD34(-), CD45(-) | [75] | |
over 500Â nm | PD-L1 | / | / | / | [76] | |
average 210.93Â nm | PS, FasL, Integrin alpha-5 | Ras homolog gene family member A, Caveolin 1, cleaved Caspase 3 | CD63, CD9 | / | [77] | |
hBMMSCs/ hADMSCs | average 175.1Â nm(hBMSCs)/183.2Â nm(hASCs) | PS | / | CD9, CD63, CD81 | CD29(+), CD44(+), CD90(+), CD34(-), CD45(-) | [78] |
hADMSCs | average 298.2Â nm | PS | cleaved Caspase 3 | TSG101, CD63 | / | [79] |
mADMSCs | 531–1110 nm | / | Component 3b, Complement C1q Subcomponent C, histone3.3, histone 2B | / | / | [80] |
SHED | average 280Â nm | PS | cleaved Caspase 3 | / | / | [81] |
100–200 nm | PS, PD1 | cleaved Caspase 3 | / | / | [82] | |
hDPSCs | average 200Â nm | / | / | CD63, CD81, TSG 101 | / | [83] |
unspecified | 600–1200 nm | C1q, PS, Fractalkine/CX3C chemokine ligand 1 | / | / | CD90(+), CD105(+) | [84] |