Fig. 7

The molecular docking results between hypoxanthine and key molecules in the hematopoietic cell lineage and MAPK signaling pathways. (A-E). The molecular docking results of hypoxanthine with critical molecules in the hematopoietic cell lineage pathway, including Cd38, Cd33, Il7r, Il2ra, and Cd19. (F-L) The docking results between hypoxanthine and key molecules in the MAPK signaling pathway, such as Il1b, Dusp1, Map3k8, Fas, Hspa1a, Hspa1b, and Tnf. For each docking diagram, the left panel displays the relative positioning of hypoxanthine and the protein within the binding pocket, while the right panel provides a detailed depiction of the binding pocket. The protein is shown with its surface structure, and hypoxanthine along with the amino acid residues involved in the binding are represented as stick models. The hydrogen bonds between the two are shown as yellow dashed lines, with the bond length labeled for each interaction