Fig. 5

Preparation and characterization of separable microneedle patches. (A) Schematic diagram of the preparation of microneedles using the microneedle mold method. (B) Scanning electron microscope (SEM) images of microneedles. (C) Representative fluorescence images of microneedles, with microneedle matrix HA-TPS labeled with rhodamine B and DPSC IVs labeled with PKH67. Scale bar: 200 μm. (D) Simulated representative images of microneedles in body fluids taken continuously at different times. Scale bar: 200 μm. (E) Force displacement curves of HA and HA-TPS microneedles. (F) DPSC cell vesicles slow-release curve of microneedles in simulated body fluids