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Table 1 Preclinical trial of MSCs injection for SUI in Women

From: Progress of mesenchymal stem cells affecting extracellular matrix metabolism in the treatment of female stress urinary incontinence

Study

Animals/Model

Stem cell source

Cell count (/mL)/reagent volume

Route of injection

Compositional changes in periurethral/vaginal ECM after injection

Measurement situation

Lin et al. [59]

Rat /VD + ovariectomy

Rat ADSCs

1 × 106

Intravenous injection into the urethra or tail vein

Significant increase in periurethral elastin content

LPP was significantly elevated

Dissaranan et al. [60]

Rat /VD

Rat BMSCs, CCM

2 × 106

Lateral caudal vein injection

Significant increase in elastin fibers around the urethra

LPP significantly elevated, EUS EMG not improved

Deng et al. [61]

Rat /VD + PNC

Rat BMSCs, CCM

2 × 106

Tail vein injection

Periurethral elastin fibers are reoriented, and density increases near EUS.

LPP and PNSBP accelerated recovery, but EUS EMG did not improve significantly

Bilhar et al. [62]

Rat /VD

Rat MDSCs

1 × 106

Medial tail vein injection

Increased expression of type I collagen and type III collagen around the urethra

unmeasured

Janssen et al. [63]

Rat /VD + PNC

Rat BMSCs

2/4/6 × 106(private injection)

Lateral caudal vein injection

Thickening of elastin fibers around the urethra

LPP was significantly elevated, with no significant effect of EUS EMG or PNENG

Zhang et al. [64]

Rat / Abdominal urethral lysis

Rat BMSCs

2 × 106

Wall of the urethra injection

Increased levels of periurethral elastin, type I collagen, and type III collagen

LPP was significantly elevated

Jiang et al. [65]

Rat /VD + PNC

Rat BMSCs-CCR1 + CCL7

2 × 106

Intravenous injection

Significant increase in the percentage of collagen around the urethra

LPP, EUS EMG, and PNMBP were all significantly elevated

Paz et al. [23]

Rat /VD

Human DMSCs

Two injections of 2 × 106 each (one week apart)

Bilateral injections into the periurethral area

The presence of larger elastic fibers around the urethra

LPP was significantly elevated

Sadeghi et al. [66]

Rat /VD

Human BMSCs

1 × 106

Periurethral or intravenous injection

The ratio of total urethral connective tissue area to total urethral tissue area was significantly elevated.

LPP was significantly elevated

Janssen et al. [67]

Rat /VD + PNC

Human BMSCs

2 × 106

Intravenous injection

Increased elastic fiber density and decreased collagen deposition in the vaginal wall

LPP, EUS EMG were not significantly elevated

Jiang et al. [68]

Rat /VD

Human BMSCs, CCM

0.4 ml

Periurethral injection

Significantly increased collagen content in tissues of the mid-urethra and adjacent anterior vaginal wall

LPP was significantly elevated

  1. VD: Vaginal Dilatation, PNC: pudendal nerve crush, EUS EMG: external urethral sphincter electromyography, PNENG: pudendal nerve electroneurogram, PNSBP: pudendal nerve sensory branch potential, PNMBP: pudendal nerve motor branch potentials, ADSCs: adipose mesenchymal stem cells, BMSCs: bone marrow mesenchymal stem cells, DMSCs: decidual mesenchymal stem cells, LPP: leak point pressure, CCM: concentrated conditioned medium