Fig. 1

Single-cell RNA sequencing landscape of ADRCs integrated from 14 patients. A Left; Uniform manifold approximation and projection (UMAP) 2D visualization of 111,983 ADRCs in 24 clusters falling into four major and one minor cell categories: endothelial- (EC), immune- (IC), perivascular mural- (PC), adipose stem/progenitor- (AC) and red blood (RBC) cells. Right; Dendrogram showing the hierarchical relationship between the 24 ADRC clusters. B–E DimPlot UMAP with subcluster annotation,—fractions (%) and violin plot of selected genes for each of the major cell types i.e. B endothelial- (EC1-4), C perivascular mural- (PC1-3), D immune- (IC1-9), and E adipose stem/progenitor (AC1-7) cells. MyoFCs: myofibrocytes, vSMC: vascular smooth muscle cells, Mϕ: Macrophages, Mo/DC: Monocyte/dendritic cells, LAM: lipid associated macrophages, NKT: natural killer T-cells, APC: adipose precursor cells, CPA: committed preadipocytes, FAP: fibroblast and adipogenic progenitor cells