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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Thrombin-preconditioned mesenchymal stromal cell-derived extracellular vesicles attenuate experimental necrotizing enterocolitis

Fig. 3

Intraperitoneal administration of thMSC-EVs attenuated the histological damage in NEC-induced mouse pups.(A) Representative microscopic images of H&E-stained histology slides. (B) Bar graph representation of histological damage score assessment. n = 11, 21, and 25 in the CON, NEC, and NEC + thEV groups, respectively. (C) Representative microscopic images of immunofluorescent staining. (D) Bar graph representation of quantification of MUC2 (+) cells. n = 6, 7, and 11 in the CON, NEC, and NEC + EV groups, respectively. Data are presented as mean ± SEM. *, p < 0.01 vs. CON; #, p < 0.01 vs. NEC. One-way ANOVA and the post-hoc Bonferroni test were used in the analysis. CON, normal control; NEC, necrotizing enterocolitis control group; NEC + thEV, thMSC-EVs treated NEC group

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Stem Cell Research & Therapy

ISSN: 1757-6512