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Table 1 Rubric for the clinical sickness score

From: Thrombin-preconditioned mesenchymal stromal cell-derived extracellular vesicles attenuate experimental necrotizing enterocolitis

Clinical Sickness Score Rubric

Score

Appearance

Respiration

Response to Touch

Natural Activity

Body Color

0

Tonic & well hydrated

Normal

Alert without stimulation

Normal

Pink

1

Slimmer but still tonic & hydrated

Gasping

Responding to mild stimulation

Able to strongly wriggle if placed supine

Pale extremities

2

Skinny, floppy, & dehydrated

Visible chest retraction

Responding to vigorous stimulation

Able to weakly wriggle if placed supine

Pale body

3

Gasping & in agony

Unable to breathe

Unresponsive

Not moving & lying still

Gray