Fig. 5

Proteomic analysis of HUVECs and HUVECs-ApoVs. (A) PCA of proteomic data. PCA1 and PCA2 represent the largest sources of variation. (B) Volcano plots of differentially expressed proteins in HUVECs before and after ApoVs intervention. (C) Heatmap of differentially expressed proteins related to signal transduction and angiogenesis. (D) GO analysis of the significantly differentially expressed proteins in ApoVs and the top 20 genes associated with (D) biological processes and (E) cellular components