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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Mesenchymal stromal/stem cells from perinatal sources: biological facts, molecular biomarkers, and therapeutic promises

Fig. 3

Mechanism of action of CD105 through TGF-β receptor complex. CD105 is first associated with receptor TGR-βR2. This association allows the binding of TGF-β 1 or 3 ligands to the complex. The binding of these ligands to the receptor complex will then activate TGF-βR2 to phosphorylate TGF-βR1. Phosphorylation of TGF-βR1, also known as activin receptor-like kinase (ALK), will initiate two intracellular downstream signaling pathways that are activated by two different subtypes of TGF-βR1 (ALK1 or ALK5). Created in https://BioRender.com

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Stem Cell Research & Therapy

ISSN: 1757-6512