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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Mesenchymal stromal/stem cells from perinatal sources: biological facts, molecular biomarkers, and therapeutic promises

Fig. 7

The suggested mechanism of action of 5-azacytidine (5-AZA) in inducing MSC differentiation into Cardiomyocytes. 5-AZA inhibits MSC proliferation by suppressing the expression of Nanog and Sox2. It is anticipated that 5-AZA is acting through Notch and MAPK pathways to stimulate the expression of cardiac-specific genes and eventually induce differentiation into cardiomyocytes. Abbreviations: DLL4, delta-like 4 ligand; GATA4, GATA-binding protein 4; Nkx2.5, NK-2 homeobox 5 protein; cTnT, cardiac troponin T; ANP, A-type natriuretic peptide

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Stem Cell Research & Therapy

ISSN: 1757-6512