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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: The local pulsatile parathyroid hormone delivery system induces the osteogenic differentiation of dental pulp mesenchymal stem cells to reconstruct mandibular defects

Fig. 6

Immunohistochemical staining results for Runx2, OCN, and OPN and semiquantitative scoring. (A-F) Immunohistochemistry 2 weeks post-surgery. (G-L) Immunohistochemistry 4 weeks post-surgery. (M-O) Semiquantitative analysis of immunohistochemistry (IOD) values. Defects: mandibular defect; blank system: blank delivery system; DPSC: dental pulp stem cell; PTH system: PTH delivery system; DPSC + blank system: dental pulp stem cell + blank delivery system; DPSC + PTH system: dental pulp stem cell + PTH delivery system. The black boxes indicate enlarged areas, and the red arrows indicate positive staining. Scale bars, (A-L) 100 μm and (a - l): 10 μm. Statistical significance: *p < 0.05, **p < 0.01, ***p < 0.001,****p < 0.0001, versus defect group; #p < 0.05, ##p < 0.01, ###p < 0.001, ####p < 0.0001, versus DPSCs + PTH system group

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Stem Cell Research & Therapy

ISSN: 1757-6512