Fig. 7

Functional testing of transplants to immunosuppressed RD rats. a Optokinetic testing of transplanted RD rats (red bars), compared with age-matched non-surgery RD controls (AMC) and sham surgeries (Data of both AMC and sham combined because of low N; green bars). Note that the transplants were always placed into the left eye at the age of 30–48 d. One month post-surgery: transplants n = 4; sham + AMC n = 3; 2 months post-surgery: transplants n = 4; sham + AMC n = 9; 3 months post-surgery: transplants n = 5; sham + AMC n = 3; 4 months post-surgery: transplants n = 3; sham + AMC n = 2; 5 months of surgery: transplants n = 3; sham + AMC n = 3. The number of experiments was lower for older ages as there was some mortality and rats were euthanized for immune cell phenotyping by flow cytometry and histology. b Example of SC recording maps of non-surgery AMC (age = 233 d), sham surgery (age = 225 d), and transplant (age = 223 d). No responses to light could be recorded